Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation
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چکیده
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15 صفحه اولEmerging concepts in the Ras superfamily of GTP-binding proteins.
The Ras superfamily of GTP-binding proteins (> 50 members) regulates a diverse spectrum of intracellular processes. These include cellular proliferation and differentiation, intracellular vesicular trafficking, cytoskeletal control, NADPH oxidase function, as well as others. In this review, we describe recent progress and emerging themes in the action and regulation of these important cellular ...
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Nucleotide Binding Switches the Information Flow in Ras GTPases
The Ras superfamily comprises many guanine nucleotide-binding proteins (G proteins) that are essential to intracellular signal transduction. The guanine nucleotide-dependent intrinsic flexibility patterns of five G proteins were investigated in atomic detail through Molecular Dynamics simulations of the GDP- and GTP-bound states (S(GDP) and S(GTP), respectively). For all the considered systems,...
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ژورنال
عنوان ژورنال: npj Genomic Medicine
سال: 2016
ISSN: 2056-7944
DOI: 10.1038/npjgenmed.2016.36